βWe found that cutting the genome with CRISPR-Cas9 induced the activation of β¦ p53,β said Emma Haapaniemi, the lead author of the Karolinska study. That βmakes editing much more difficult.βYet more trouble for the approach. I think the knowledge about the new type of DNA needs to be expanded before we truly understand this.
The flip side of p53 repairing CRISPR edits, or killing cells that accept the edits, is that cells that survive with the edits do so precisely because they have a dysfunctional p53 and therefore lack this fix-it-or-kill-it mechanism.
The reason why that could be a problem is that p53 dysfunction can cause cancer. And not just occasionally. P53 mutations are responsible for nearly half of ovarian cancers; 43 percent of colorectal cancers; 38 percent of lung cancers; nearly one-third of pancreatic, stomach, and liver cancers; and one-quarter of breast cancers, among others.
I discovered that the world should be divided not into good and bad people but into cowards and non-cowards. Ninety-five percent of cowards are capable of the vilest things, lethal things, at the mildest threat.Damn straight.
I am convinced that the campsβall of themβare a negative school; you canβt even spend an hour in one without being depraved. The camps never gave, and never could give, anyone anything positive. The camps act by depraving everyone, prisoners and free-contract workers alike.
I realized that the thieves were not human.
Word had gotten around about the questions I was asking, and an omerta was in effect.Glad to hear they're being smart up there.
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